Journal article

Self-reported confusion is related to global and regional beta-amyloid: data from the Women's healthy ageing project

Georgia E McCluskey, Paul Yates, Victor L Villemagne, Christopher Rowe, Cassandra EI Szoeke

BRAIN IMAGING AND BEHAVIOR | SPRINGER | Published : 2018

Abstract

Disease-modifying treatments for Alzheimer's disease (AD) may require implementation during early stages of β-amyloid accumulation, well before patients have objective cognitive decline. In this study we aimed to assess the clinical value of subjective cognitive impairment (SCI) by examining the cross-sectional relationship between β-amyloid load and SCI. Cerebral β-amyloid and SCI was assessed in a cohort of 112 cognitively normal subjects. Subjective cognition was evaluated using specific questions on memory and cognition and the MAC-Q. Participants had cerebral β-amyloid load measured with 18F-Florbetaben Positron Emission Tomography (PET). No associations were found between measures of s..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Alzheimer's Association


Funding Acknowledgements

We would like to acknowledge the contribution of participants, team members, partners and their supporters who have given their time and patience for over 20 years to the university. A full list of all researchers contributing to the WHAP and membership of our Scientific Advisory Board is available at www.whap.unimelb.edu.au. Funding for the WHAP has been provided by the Australian National Health and Medical Research Council (NHMRC 1062133, 547600, 1032350), Bayer Healthcare, the Ramaciotti Foundation, the Brain Foundation, the Alzheimer's Association of Australia, the Australian Menopausal Society, the Shepherd Foundation, the Scobie and Claire Mackinnon Trust, the Collier Trust Fund, the J.O. & J.R. Wicking Trust, the Mason Foundation and the Alzheimer's Association (NIA320312). Inaugural funding was provided by VicHealth and the NHMRC.