Central mechanisms of airway sensation and cough hypersensitivity
Alexandria K Driessen, Alice E McGovern, Monica Narula, Seung-Kwon Yang, Jennifer A Keller, Michael J Farrell, Stuart B Mazzone
PULMONARY PHARMACOLOGY & THERAPEUTICS | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2017
The airway sensory nervous system is composed of two anatomically distinct processing pathways that allow for the production of respiratory reflexes and voluntary evoked respiratory behaviours in response to sensing an airway irritation. Disordered sensory processing is a hallmark feature of many pulmonary disorders and results in the development of cough hypersensitivity syndrome, characterised by chronic cough and a persistent urge-to-cough in affected individuals. However, the mechanism underpinning how the airway sensory circuits become disordered, especially at the level of the central nervous system, is not well understood. In this mini-review we present well-defined mechanisms that le..View full abstract
Related Projects (1)
Awarded by NHMRC of Australia
NHMRC of Australia. #1078943.