Journal article
Polyunsaturated fatty acid biostatus, phospholipase A2 activity and brain white matter microstructure across adolescence
RK McNamara, PR Szeszko, S Smesny, T Ikuta, P DeRosse, FM Vaz, B Milleit, UC Hipler, C Wiegand, J Hesse, GP Amminger, AK Malhotra, BD Peters
Neuroscience | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Abstract
Adolescence is a period of major brain white matter (WM) changes, and membrane lipid metabolism likely plays a critical role in brain WM myelination. Long-chain polyunsaturated fatty acids (LC-PUFAs) are essential components of cell membranes including oligodendrocytes, and LC-PUFA release and turnover in membranes is regulated by phospholipase A2 enzymes. To investigate the role of membrane lipid metabolism in healthy WM myelination across adolescence, the present study examined the relationship between membrane LC-PUFA biostatus, phospholipase A2 activity, and brain WM microstructure in healthy subjects aged 9–20 years (n = 30). Diffusion tensor imaging (DTI) was performed to measure avera..
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Awarded by National Institutes of Health
Funding Acknowledgements
Funding for this study was supported in part by grants from the National Institutes of Health to Dr. Szeszko (R01 MH076995), to Dr. McNamara (DK097599), the NSLIJ Research Institute General Clinical Research Center (M01 RR018535), an Advanced Center for Intervention and Services Research (P30 MH090590) and a Center for Intervention Development and Applied Research (P50 MH080173 to Dr. Malhotra), and by a NARSAD grant from the Brain and Behavior Research Foundation to Dr. Peters (2013). The funding sources had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.