Journal article

Childhood maltreatment, psychopathology, and the development of hippocampal subregions during adolescence

Sarah Whittle, Julian G Simmons, Sylke Hendriksma, Nandita Vijayakumar, Michelle L Byrne, Meg Dennison, Nicholas B Allen

BRAIN AND BEHAVIOR | WILEY | Published : 2017

Abstract

INTRODUCTION: It is well established that childhood maltreatment has a detrimental impact on the brain, particularly the hippocampus. However, the hippocampus is a functionally and structurally heterogeneous region, and little is known about how maltreatment might affect hippocampal subregion development throughout important periods of plasticity. This study investigated whether childhood maltreatment was associated with the development of hippocampal subregion volumes from early to late adolescence. It also investigated associations between onset of psychiatric disorder and hippocampal subregion volume development. METHODS: One hundred and sixty-six (85 male) adolescents took part in three ..

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