Journal article
Gestational diabetes mellitus and retinal microvasculature
LJ Li, M Kramer, RJ Tapp, REK Man, N Lek, S Cai, F Yap, P Gluckman, KH Tan, YS Chong, JY Koh, SM Saw, YB Cheung, TY Wong
BMC Ophthalmology | BMC | Published : 2017
Abstract
Background: Small-vessel dysfunction may be an important consequence of chronic hyperglycemia. We examined the association between gestational diabetes mellitus (GDM), a state of transient hyperglycemia during pregnancy, and retinal microvascular changes in pregnant women at 26-28 weeks of pregnancy. Methods: A total of 1136 pregnant women with singleton pregnancies were recruited during their first trimester at two major Singapore maternity hospitals in an on-going birth cohort study. Participants underwent an oral glucose tolerance test and retinal imaging at 26-28 weeks gestation (n = 542). We used the 1999 World Health Organization (WHO) criteria to define GDM: ≥7.0 mmol/L for fasting gl..
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Funding Acknowledgements
This study is under the Translational Clinical Research (TCR) Flagship Program on Developmental Pathways to Metabolic Disease, NMRC/TCR/004-NUS/2008 funded by the National Research Foundation (NRF) and administered by the National Medical Research Council (NMRC), Singapore.