Does genetic BDNF deficiency in rats interact with neurotransmitter control of prepulse inhibition? Implications for schizophrenia
Maarten van den Buuse, Davina Biel, Kathrin Radscheit
Progress in Neuro-Psychopharmacology and Biological Psychiatry | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Several studies have suggested a role of BDNF in the development of schizophrenia. For example, post-mortem studies have shown significantly reduced levels of BDNF protein expression in the brain of schizophrenia patients. We investigated the relationship between reduced levels of BDNF in the brain and the regulation of prepulse inhibition (PPI), a behavioral endophenotype of schizophrenia. We used BDNF heterozygous mutant rats which display a 50% decrease of mature BDNF protein levels. Previously, we observed normal baseline PPI and responses to the dopamine D1/D2 receptor agonist, apomorphine, in these rats. Here, we focused on the effects of the NMDA receptor antagonist, MK-801, its inter..View full abstract
Awarded by National Health and Medical Research Council of Australia
This study was supported by a Senior Research Fellowship from the National Health and Medical Research Council of Australia (1041895). This organization had no role in the study design, the collection, analysis and interpretation of the data, the writing of this report, or the decision to submit the article for publication. The authors have no actual or potential conflicts of interest to disclose.