Optimization of 2-Anilino 4-Amino Substituted Quinazolines into Potent Antimalarial Agents with Oral in Vivo Activity
Paul R Gilson, Cyrus Tan, Kate E Jarman, Kym N Lowes, Joan M Curtis, William Nguyen, Adrian E Di Rago, Hayley E Bullen, Boris Prinz, Sandra Duffy, Jonathan B Baell, Craig A Hutton, Helene Jousset Subroux, Brendan S Crabb, Vicky M Avery, Alan F Cowman, Brad E Sleebs
Journal of Medicinal Chemistry | AMER CHEMICAL SOC | Published : 2017
Awarded by National Health and Medical Research Council of Australia
Awarded by Australian Research Council
This work was funded by the National Health and Medical Research Council of Australia (Program Grant APP1092789), the Australian Cancer Research Foundation, Brian Little Bequest, Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIISS. A.F.C. is a Howard Hughes International Scholar and an Australia Fellow of the NHMRC. We thank and acknowledge the Australian Red Cross Blood Bank for the provision of fresh red blood cells, without which this research could not have been performed. This work was supported by the Australian Research Council (LP120200557 to V.M.A.). We thank Associate Professor Guillaume Lessene, Dr. Andrew Powell, and Professor Susan Charman for their helpful discussions, and Halina M. Pietrzak for technical assistance.