Understanding the cochlear implant environment by mapping perilymph proteomes from different species
Jonathan C Palmer, Megan S Lord, Jeremy L Pinyon, Andrew K Wise, Nigel H Lovell, Paul M Carter, Ya Lang Enke, Gary D Housley, Rylie A Green, J Patton (ed.), R Barbieri (ed.), J Ji (ed.), E Jabbari (ed.), S Dokos (ed.), R Mukkamala (ed.), D Guiraud (ed.), E Jovanov (ed.), Y Dhaher (ed.), D Panescu (ed.), M Vangils (ed.) Show all
Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) | IEEE | Published : 2016
Cochlear implants operate within a bony channel of the cochlea, bathed in a fluid known as the perilymph. The perilymph is a complex fluid containing ions and proteins, which are known to actively interact with metallic electrodes. To improve our understanding of how cochlear implant performance varies in preclinical in vivo studies in comparison to human trials and patient outcomes, the protein composition (or perilymph proteome) is needed. Samples of perilymph were gathered from feline and guinea pig subjects and analyzed using liquid chromatography with tandem mass spectrometry (LC-MS/MS) to produce proteomes and compare against the recently published human proteome. Over 64% of the prote..View full abstract
Awarded by ARC
Research supported by ARC Linkage grant LP140100109 and Cochlear Ltd.Mass spectrometric analysis for this work was carried out at the Bioanalytical Mass Spectrometry Facility, UNSW and was supported in part by infrastructure funding from the New South Wales Government as part of its co-investment in the National Collaborative Research Infrastructure Strategy.