Annexin Al influences in breast cancer: Controversies on contributions to tumour, host and immunoediting processes
Yan Tu, Cameron N Johnstone, Alastair G Stewart
Pharmacological Research | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD | Published : 2017
Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer im..View full abstract
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Awarded by NHMRC
The authors' work cited in this review was supported by a grant from NHMRC#1023185.