Opportunities and Challenges for Psychiatry in the Connectomic Era
Alex Fornito, Edward T Bullmore, Andrew Zalesky
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING | ELSEVIER | Published : 2017
Most major psychiatric disorders arise from disturbances of anatomically distributed neural systems rather than isolated dysfunction of circumscribed brain regions. The past decade has witnessed rapid advances in our capacity to measure, map, and model neural connectivity in diverse species and at different resolution scales, from the level of individual neurons and synapses to large-scale systems spanning the entire brain. In this review, we consider how these techniques, when grounded in the theory and methods of network science, can contribute to a biological understanding of mental illness. We focus in particular on attempts to accurately map brain network disturbances in clinical popula..View full abstract
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Awarded by Australian Research Council
Awarded by National Health and Medical Research Council
This work was supported by the Australian Research Council (Grant No. FT130100589 to AF), the National Health and Medical Research Council (Grant Nos. 1050504 and 1066779 [to AF] and 1047648 and 1103252 [to AZ]), and the Wellcome Trust and the National Institute of Health Research (to ETB).