Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: Network meta-analysis

Abstract

Background Few trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional metaanalyses provided limited comparisons between therapies. Aims To combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA). Method Systematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF). Results Carer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combinat..