Journal article
Bipolar At-Risk Criteria: An Examination of Which Clinical Features Have Optimal Utility for Identifying Youth at Risk of Early Transition from Depression to Bipolar Disorders
J Scott, S Marwaha, A Ratheesh, I Macmillan, AR Yung, R Morriss, IB Hickie, A Bechdolf
Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2017
Abstract
Background: A clinical and research challenge is to identify which depressed youth are at risk of "early transition to bipolar disorders (ET-BD)." This 2-part study (1) examines the clinical utility of previously reported BD at-risk (BAR) criteria in differentiating ET-BD cases from unipolar depression (UP) controls; and (2) estimates the Number Needed to Screen (NNS) for research and general psychiatry settings. Methods: Fifty cases with reliably ascertained, ET-BD I and II cases were matched for gender and birth year with 50 UP controls who did not develop BD over 2 years. We estimated the clinical utility for finding true cases and screening out non-cases for selected risk factors and the..
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Awarded by Research for Patient Benefit Programme UK
Awarded by National Institutes of Health Research (NIHR)
Awarded by National Institute for Health Research
Funding Acknowledgements
J.S. has received grant funding from the Stanley Foundation (for work on lithium and medication adherence), from the Medical Research Council UK (including for projects on bipolar II disorders, on CBT and on actigraphic monitoring in bipolar disorders) and from the Research for Patient Benefit Programme UK (PB-PG-0609-16166: Early identification and intervention in young people at risk of mood disorders). She has not received any Pharma funding in the last 5 years.