Journal article

Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke

Grant Mair, Ruediger von Kummer, Alessandro Adami, Philip M White, Matthew E Adams, Bernard Yan, Andrew M Demchuk, Andrew J Farrall, Robin J Sellar, Eleni Sakka, Jeb Palmer, David Perry, Richard I Lindley, Peter AG Sandercock, Joanna M Wardlaw

STROKE | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017

Abstract

BACKGROUND AND PURPOSE: Computed tomographic angiography and magnetic resonance angiography are used increasingly to assess arterial patency in patients with ischemic stroke. We determined which baseline angiography features predict response to intravenous thrombolytics in ischemic stroke using randomized controlled trial data. METHODS: We analyzed angiograms from the IST-3 (Third International Stroke Trial), an international, multicenter, prospective, randomized controlled trial of intravenous alteplase. Readers, masked to clinical, treatment, and outcome data, assessed prerandomization computed tomographic angiography and magnetic resonance angiography for presence, extent, location, and c..

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Grants

Awarded by National Institute for Health Research (NIHR) Efficacy and Mechanisms Evaluation Panel


Awarded by UK Medical Research Council


Awarded by Edinburgh MRC Hub for Trials Methodology Research - UK MRC


Awarded by Medical Research Council


Awarded by Alberta Innovates


Funding Acknowledgements

IST-3 angiography substudy (Third International Stroke Trial) was funded by the National Institute for Health Research (NIHR) Efficacy and Mechanisms Evaluation Panel (EME-08-43-52). Main IST-3 trial had many funders detailed in Appendix IV in the online-only Data Supplement, primarily the UK Medical Research Council (MRC G0400069 and EME-09-800-15). Systematic Image Review System V2 (SIRS-2) development was funded by the Edinburgh MRC Hub for Trials Methodology Research funded by the UK MRC (G0800803).