Journal article

Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system

KKC Man, D Coghill, EW Chan, WCY Lau, C Hollis, E Liddle, T Banaschewski, S McCarthy, A Neubert, K Sayal, P Ip, ICK Wong



Previous studies have suggested that risk of psychotic events may be increased in children exposed to methylphenidate (MPH). However, this risk has not been fully examined, and the possibility of confounding factors has not been excluded. Patients aged 6-19 years who received at least one MPH prescription were identified using Hong Kong population-based electronic medical records on the Clinical Data Analysis and Reporting System (2001-2014). Using the self-controlled case series design, relative incidence of psychotic events was calculated comparing periods when patients were exposed to MPH with non-exposed periods. Of 20,586 patients prescribed MPH, 103 had an incident psychotic event; 72 ..

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Awarded by European Community

Awarded by National Institute for Health Research

Funding Acknowledgements

The Attention Deficit Hyperactivity Disorder Drugs Use Chronic Effects (ADDUCE) project, European Community's 7th framework programme project number 260576, has partly funded this project. We thank the Hong Kong HA for access to the data from CDARS for research purposes. We also thank Ms Lisa Wong for editing and proofreading the manuscript and Ms Andrea Bilbow for involving setting the research questions as a lay member of ADDUCE project.