DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

Grants

Funding Acknowledgements

Model coordinates have been deposited in the Protein Data Bank under accession number 5LUQ. We thank J. Van den Heuvel at Helmholtz-Zentrum and particularly V. Jager, who prepared the HeLa cells. We are also grateful to the European Synchrotron Radiation Facility (beamlines ID29, ID14-1, and 1D14-2 in Grenoble, France) and Diamond (beamlines I04 and I03 in Oxford, UK) synchrotron sources, where the data were collected. This work was funded by the Wellcome Trust (grant 093167/Z/10/Z).