DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair
Bancinyane L Sibanda, Dimitri Y Chirgadze, David B Ascher, Tom L Blundell
Science | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2017
Awarded by Wellcome Trust
Awarded by Biotechnology and Biological Sciences Research Council
Model coordinates have been deposited in the Protein Data Bank under accession number 5LUQ. We thank J. Van den Heuvel at Helmholtz-Zentrum and particularly V. Jager, who prepared the HeLa cells. We are also grateful to the European Synchrotron Radiation Facility (beamlines ID29, ID14-1, and 1D14-2 in Grenoble, France) and Diamond (beamlines I04 and I03 in Oxford, UK) synchrotron sources, where the data were collected. This work was funded by the Wellcome Trust (grant 093167/Z/10/Z).