Journal article
Association between CD8 T-cell infiltration and breast cancer survival in 12 439 patients
HR Ali, E Provenzano, SJ Dawson, FM Blows, B Liu, M Shah, HM Earl, CJ Poole, L Hiller, JA Dunn, SJ Bowden, C Twelves, JMS Bartlett, SMA Mahmoud, E Rakha, IO Ellis, S Liu, D Gao, TO Nielsen, PDP Pharoah Show all
Annals of Oncology | OXFORD UNIV PRESS | Published : 2014
Abstract
Background: T-cell infiltration in estrogen receptor (ER)-negative breast tumours has been associated with longer survival. To investigate this association and the potential of tumour T-cell infiltration as a prognostic and predictive marker, we have conducted the largest study of T cells in breast cancer to date. Patients and methods: Four studies totalling 12 439 patients were used for this work. Cytotoxic (CD8+) and regulatory (forkhead box protein 3, FOXP3+) T cells were quantified using immunohistochemistry (IHC). IHC for CD8 was conducted using available material from all four studies (8978 samples) and for FOXP3 from three studies (5239 samples)-multiple imputation was used to resolve..
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Awarded by National Institute for Health Research
Funding Acknowledgements
This work was supported by Cancer Research UK (C490/A10119 and C490/A10124) and the NIHR Cambridge Biomedical Research Centre. HRA was supported by a grant from Addenbrooke's Charitable Trust and is now an NIHR Academic Clinical Lecturer supported by a Career Development Fellowship from the Pathological Society of Great Britain and Northern Ireland. The BCCA study was supported by an unrestricted educational grant from Sanofi-Aventis Canada. SMAM was supported by a PhD studentship funded by the Government of Egypt. IOE was funded by Breast Cancer Campaign.