Journal article

Breast cancer susceptibility risk associations and heterogeneity by E-cadherin tumor tissue expression

Hisani N Horne, Mark E Sherman, Montserrat Garcia-Closas, Paul D Pharoah, Fiona M Blows, Xiaohong R Yang, Stephen M Hewitt, Catherine M Conway, Jolanta Lissowska, Louise A Brinton, Ludmila Prokunina-Olsson, Sarah-Jane Dawson, Carlos Caldas, Douglas F Easton, Stephen J Chanock, Jonine D Figueroa



E-cadherin is involved in cell-cell adhesion and epithelial-to-mesenchymal transitions. In cancers, loss or inactivation of E-cadherin is associated with epithelial cell proliferation and invasion. Here, we sought to determine, if risk associations for 18 breast cancer susceptibility single nucleotide polymorphisms (SNPs) differed by E-cadherin tumor tissue expression in the Polish Breast Cancer Study (PBCS), using data on 1,347 invasive breast cancer cases and 2,366 controls. E-cadherin expression (low/high) was assessed using immunohistochemical staining of tumor tissue microarrays. Replication data on 2,006 cases and 6,714 controls from the Study of Epidemiology and Risk Factors in Cancer..

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University of Melbourne Researchers


Awarded by Cancer Research UK

Awarded by Cancer Research UK; The Francis Crick Institute

Awarded by National Institute for Health Research

Funding Acknowledgements

This research was supported by the Intramural Research Programs of the Division of Cancer Epidemiology and Genetics and Center for Cancer Research of the National Cancer Institute. M. Garcias-Closas is funded by the Breakthrough Breast Cancer Centre and the Institute of Cancer Research, London, UK. We acknowledge NHS funding to the Royal Marsden/ICR NIHR Biomedical Research Centre.