Journal article

Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium

William J Howat, Fiona M Blows, Elena Provenzano, Mark N Brook, Lorna Morris, Patrycja Gazinska, Nicola Johnson, Leigh-Anne McDuffus, Jodi Miller, Elinor J Sawyer, Sarah Pinder, Carolien HM van Deurzen, Louise Jones, Reijo Sironen, Daniel Visscher, Carlos Caldas, Frances Daley, Penny Coulson, Annegien Broeks, Joyce Sanders Show all

Journal of Pathology: Clinical Research | WILEY | Published : 2015


Awarded by Dutch Cancer Society

Awarded by Dutch government

Awarded by Fondo de Investigacion Sanitario

Awarded by Academy of Finland

Awarded by NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer

Awarded by Biobanking and Biomolecular Resources Research Infrastructure

Awarded by Yorkshire Cancer Research

Awarded by Cancer Research UK

Awarded by European CommunityCs Seventh Framework Programme

Awarded by Academy of Medical Sciences (AMS)

Awarded by Medical Research Council

Awarded by National Institute for Health Research


Funding Acknowledgements

We would like to thank Rob Sykes from Leica Biosystems who helped to retrain the SEARCH image analysis for EGFR and CK5/6. We would also like to thank Mike Irwin at the Institute of Astronomy, Cambridge, for assistance with methods in the automated analysis. ABCS was supported by the Dutch Cancer Society [grants NKI 2007-3839; 2009 4363]; BBMRI-NL, which is a Research Infrastructure financed by the Dutch government (NWO 184.021.007); and the Dutch National Genomics Initiative. CNIO-BCS was supported by the Genome Spain Foundation, the Red Tematica de Investigacion Cooperativa en Cancer and grants from the Asociacion Espanola Contra el Cancer and the Fondo de Investigacion Sanitario (PI11/00923 and PI081120). The Human Genotyping-CEGEN Unit (CNIO) is supported by the Instituto de Salud Carlos III. HEBCS was financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (132473), the Finnish Cancer Society, The Nordic Cancer Union and the Sigrid Juselius Foundation. The KBCP was financially supported by the special Government Funding (EVO) of Kuopio University Hospital grants, Cancer Fund of North Savo, the Finnish Cancer Organizations, the Academy of Finland and by the strategic funding of the University of Eastern Finland. The MCBCS was supported by an NIH Specialized Program of Research Excellence (SPORE) in Breast Cancer [CA116201], the Breast Cancer Research Foundation, the Mayo Clinic Breast Cancer Registry and a generous gift from the David F. and Margaret T. Grohne Family Foundation and the Ting Tsung and Wei Fong Chao Foundation. ORIGO authors thank E. Krol-Warmerdam, and J. Blom; The contributing studies were funded by grants from the Dutch Cancer Society (UL1997-1505) and the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL CP16). PBCS was funded by Intramural Research Funds of the National Cancer Institute, Department of Health and Human Services, USA. SBCS was supported by Yorkshire Cancer Research S295, S299, S305PA. SEARCH is funded by programme grant from Cancer Research UK [C490/A10124. C490/A16561] and supported by the UK National Institute for Health Research Biomedical Research Centre at the University of Cambridge. Part of this work was supported by the European CommunityCs Seventh Framework Programme under grant agreement number 223175 (grant number HEALTH-F2-2009223175) (COGS). We acknowledge funds from Breakthrough Breast Cancer, UK, in support of MGC and MB.