Targeting Neutrophils to Prevent Malaria-Associated Acute Lung Injury/Acute Respiratory Distress Syndrome in Mice
Michelle K Sercundes, Luana S Ortolan, Daniela Debone, Paulo V Soeiro-Pereira, Eliane Gomes, Elizabeth H Aitken, Antonio Condino Neto, Momtchilo Russo, Maria R D' Imperio Lima, Jose M Alvarez, Silvia Portugal, Claudio RF Marinho, Sabrina Epiphanio
PLoS Pathogens | PUBLIC LIBRARY SCIENCE | Published : 2016
Malaria remains one of the greatest burdens to global health, causing nearly 500,000 deaths in 2014. When manifesting in the lungs, severe malaria causes acute lung injury/acute respiratory distress syndrome (ALI/ARDS). We have previously shown that a proportion of DBA/2 mice infected with Plasmodium berghei ANKA (PbA) develop ALI/ARDS and that these mice recapitulate various aspects of the human syndrome, such as pulmonary edema, hemorrhaging, pleural effusion and hypoxemia. Herein, we investigated the role of neutrophils in the pathogenesis of malaria-associated ALI/ARDS. Mice developing ALI/ARDS showed greater neutrophil accumulation in the lungs compared with mice that did not develop pu..View full abstract
Awarded by Sao Paulo Research Foundation (FAPESP)
Awarded by Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
Awarded by FAPESP
Financial support was provided by grants 2009/53256-7 (SE) and 2009/53889-0 (CRFM) from the Sao Paulo Research Foundation (FAPESP) and the Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) 306668/2012-2 and 470590/2009-2 (SE). SP, MKS, LSO and EHA were supported by a FAPESP fellowship (2010/11925-7, 2010/19439-4, 2013/20718-3 and 2011/19525-0, respectively). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.