Incorporation of CT-Based Measurements of Trunk Anatomy Into Subject-Specific Musculoskeletal Models of the Spine Influences Vertebral Loading Predictions
Alexander G Bruno, Hossein Mokhtarzadeh, Brett T Allaire, Kelsey R Velie, M Clara De Paolis Kaluza, Dennis E Anderson, Mary L Bouxsein
JOURNAL OF ORTHOPAEDIC RESEARCH | WILEY | Published : 2017
We created subject-specific musculoskeletal models of the thoracolumbar spine by incorporating spine curvature and muscle morphology measurements from computed tomography (CT) scans to determine the degree to which vertebral compressive and shear loading estimates are sensitive to variations in trunk anatomy. We measured spine curvature and trunk muscle morphology using spine CT scans of 125 men, and then created four different thoracolumbar spine models for each person: (i) height and weight adjusted (Ht/Wt models); (ii) height, weight, and spine curvature adjusted (+C models); (iii) height, weight, and muscle morphology adjusted (+M models); and (iv) height, weight, spine curvature, and mu..View full abstract
Awarded by National Institutes of Health
Awarded by National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study (NIH/NHLBI)
Awarded by National Space Biomedical Research Institute through NASA
Grant sponsor: National Institutes of Health; Grant numbers: R01AR053986, F31AG041629, K99AG042458; Grant sponsor: National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study (NIH/NHLBI); Grant number: N01-HC-25195; Grant sponsor: National Space Biomedical Research Institute through NASA; Grant numbers: NCC 9-58, NNX16AC15G S01.