Journal article

Incorporation of CT-Based Measurements of Trunk Anatomy Into Subject-Specific Musculoskeletal Models of the Spine Influences Vertebral Loading Predictions

Alexander G Bruno, Hossein Mokhtarzadeh, Brett T Allaire, Kelsey R Velie, M Clara De Paolis Kaluza, Dennis E Anderson, Mary L Bouxsein

Journal of Orthopaedic Research® | WILEY | Published : 2017

Abstract

We created subject-specific musculoskeletal models of the thoracolumbar spine by incorporating spine curvature and muscle morphology measurements from computed tomography (CT) scans to determine the degree to which vertebral compressive and shear loading estimates are sensitive to variations in trunk anatomy. We measured spine curvature and trunk muscle morphology using spine CT scans of 125 men, and then created four different thoracolumbar spine models for each person: (i) height and weight adjusted (Ht/Wt models); (ii) height, weight, and spine curvature adjusted (+C models); (iii) height, weight, and muscle morphology adjusted (+M models); and (iv) height, weight, spine curvature, and mu..

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University of Melbourne Researchers

Grants

Awarded by National Institutes of Health


Awarded by National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study (NIH/NHLBI)


Awarded by National Space Biomedical Research Institute through NASA


Awarded by DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS


Awarded by NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES


Awarded by NATIONAL INSTITUTE ON AGING


Funding Acknowledgements

Grant sponsor: National Institutes of Health; Grant numbers: R01AR053986, F31AG041629, K99AG042458; Grant sponsor: National Heart, Lung, and Blood Institute (NHLBI) Framingham Heart Study (NIH/NHLBI); Grant number: N01-HC-25195; Grant sponsor: National Space Biomedical Research Institute through NASA; Grant numbers: NCC 9-58, NNX16AC15G S01.