Journal article
Metastatic pathways in patients with cutaneous melanoma
Nikki R Adler, Andrew Haydon, Catriona A McLean, John W Kelly, Victoria J Mar
PIGMENT CELL & MELANOMA RESEARCH | WILEY | Published : 2017
DOI: 10.1111/pcmr.12544
Abstract
Metastasis represents the end product of an elaborate biological process, which is determined by a complex interplay between metastatic tumour cells, host factors and homoeostatic mechanisms. Cutaneous melanoma can metastasize haematogenously or lymphogenously. The three predominant models that endeavour to explain the patterns of melanoma progression are the stepwise spread model, the simultaneous spread model and the model of differential spread. The time course to the development of metastases differs between the different metastatic routes. There are several clinical and histopathological risk factors for the different metastatic pathways. In particular, patient sex and the anatomical lo..
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