Journal article
Changes in gene expression of neo-squamous mucosa after endoscopic treatment for dysplastic Barrett’s esophagus and intramucosal adenocarcinoma
A Levert-Mignon, MJ Bourke, SJ Lord, AC Taylor, AR Wettstein, M Edwards, NK Botelho, R Sonson, C Jayasekera, OM Fisher, ML Thomas, F Macrae, DJ Hussey, DI Watson, RV Lord
United European Gastroenterology Journal | SAGE PUBLICATIONS INC | Published : 2017
Abstract
Background: Endoscopic therapy, including by radiofrequency ablation (RFA) or endoscopic mucosal resection (EMR), is first line treatment for Barrett’s esophagus (BE) with high-grade dysplasia (HGD) or intramucosal cancer (IMC) and may be appropriate for some patients with low-grade dysplasia (LGD). Objective: The purpose of this study was to investigate the molecular effects of endotherapy. Methods: mRNA expression of 16 genes significantly associated with different BE stages was measured in paired pre-treatment BE tissues and post-treatment neo-squamous biopsies from 36 patients treated by RFA (19 patients, 3 IMC, 4 HGD, 12 LGD) or EMR (17 patients, 4 IMC, 13 HGD). EMR was performed prior ..
View full abstractGrants
Awarded by Cancer Council NSW
Funding Acknowledgements
This work was supported by the Australian National Health and Medical Research Council (project grant 100837) and the Cancer Council New South Wales (SRP 08-04).