Journal article
High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice
FZ Marques, E Nelson, PY Chu, D Horlock, A Fiedler, M Ziemann, JK Tan, S Kuruppu, NW Rajapakse, A El-Osta, CR Mackay, DM Kaye
Circulation | LIPPINCOTT WILLIAMS & WILKINS | Published : 2017
Abstract
BACKGROUND: Dietary intake of fruit and vegetables is associated with lower incidence of hypertension, but the mechanisms involved have not been elucidated. Here, we evaluated the effect of a high-fiber diet and supplementation with the short-chain fatty acid acetate on the gut microbiota and the prevention of cardiovascular disease. METHODS: Gut microbiome, cardiorenal structure/function, and blood pressure were examined in sham and mineralocorticoid excess-treated mice with a control diet, high-fiber diet, or acetate supplementation. We also determined the renal and cardiac transcriptome of mice treated with the different diets. RESULTS: We found that high consumption of fiber modified the..
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Funding Acknowledgements
This work was supported by a National Health & Medical Research Council of Australia Program Grant and fellowship to Prof Kaye. Dr Marques is supported by National Health & Medical Research Council of Australia and National Heart Foundation coshared Early Career Fellowships and a Foundation for High Blood Pressure Research grant and a seeding grant from the Baker Heart and Diabetes Institute. Prof El-Osta and Dr Ziemann are supported by the National Health & Medical Research Council of Australia, the Juvenile Diabetes Research Foundation, and the Diabetes Australia Research Trust. The Baker Heart and Diabetes Institute is supported in part by the Victorian Government's Operational Infrastructure Support Program. The authors acknowledge the use of Illumina sequencing at the Australian Genome Research Facility (and the support it receives from the Commonwealth of Australia).