Preventive therapy for latent tuberculosis infection-the promise and the challenges
GJ Fox, CC Dobler, BJ Marais, JT Denholm
International Journal of Infectious Diseases | ELSEVIER SCI LTD | Published : 2017
Around one third of the world's population may harbour latent tuberculosis infection (LTBI), an asymptomatic immunological state that confers a heightened risk of subsequently developing tuberculosis (TB). Effectively treating LTBI will be essential if the End TB Strategy is to be realized. This review evaluates the evidence in relation to the effectiveness of preventive antibiotic therapy to treat LTBI due to both drug-susceptible and drug-resistant bacteria. Current national and international preventive therapy guidelines are summarized, as well as ongoing randomized trials evaluating regimens to prevent drug-resistant TB. Populations that may benefit most from screening and treatment for ..View full abstract
Awarded by Australian National Health and Medical Research Council (NHMRC)
GJF was supported by a CJ Martin Fellowship from the Australian National Health and Medical Research Council (NHMRC), APP 1054107.