Screening the attachment and spreading of bone marrow-derived and adipose-derived mesenchymal stem cells on porous silicon gradients
Peng-Yuan Wang, Lauren R Clements, Helmut Thissen, Shih-Chieh Hung, Nai-Chen Cheng, Wei-Bor Tsai, Nicolas H Voelcker
RSC Advances | ROYAL SOC CHEMISTRY | Published : 2012
Nanoscale surface topography exerts profound effects on stem cell behaviour. Detailed knowledge of these effects is of key relevance to the development of advanced materials for tissue engineering. In order to gain such knowledge, high-throughput platforms for characterising cell-surface interactions are required. One suitable platform technology involves the use of lateral gradients where a continuous variation in a chemical or physical surface parameter of choice is investigated. Here, we fabricate porous silicon (pSi) gradients displaying pore sizes ranging from approximately 2 μm down to a few nm in diameter, and changing in solid surface fraction from 15% to 95% along the 12 mm length o..View full abstract
Awarded by National Science Council, Taiwan
Awarded by National Science Council, Taiwan, under Graduate Program for Studying (GPS) in Australia/New Zealand scheme
The authors gratefully acknowledge funding from the Australian Research Council and National Science Council, Taiwan (99-2221-E-002-131). Peng-Yuan Wang acknowledges support from the National Science Council, Taiwan, by award of a travel scholarship under the Graduate Program for Studying (GPS) in Australia/New Zealand scheme (98-2911-I-002-056). Lauren Clements acknowledges support from the CSIRO Food Futures Flagship.