Journal article
Therapeutic CPAP level predicts upper airway collapsibility in patients with obstructive sleep apnea
SA Landry, SA Joosten, DJ Eckert, AS Jordan, SA Sands, DP White, A Malhotra, A Wellman, GS Hamilton, BA Edwards
Sleep | WILEY-BLACKWELL | Published : 2017
DOI: 10.1093/sleep/zsx056
Abstract
Study Objectives: Upper airway collapsibility is a key determinant of obstructive sleep apnea (OSA) which can influence the efficacy of certain non-continuous positive airway pressure (CPAP) treatments for OSA. However, there is no simple way to measure this variable clinically. The present study aimed to develop a clinically implementable tool to evaluate the collapsibility of a patient's upper airway. Methods: Collapsibility, as characterized by the passive pharyngeal critical closing pressure (Pcrit), was measured in 46 patients with OSA. Associations were investigated between Pcrit and data extracted from patient history and routine polysomnography, including CPAP titration. Results: The..
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Awarded by National Institutes of Health
Funding Acknowledgements
Dr. Landry is supported by NeuroSleep, a NHMRC Centre of Research Excellence (1060992) as well as the Monash University Faculty of Medicine, Nursing and Health Sciences postdoctoral bridging Fellowship. Dr Eckert is supported by a NHMRC Senior Research Fellowship (1116942). Dr Jordan is supported by the Australian Research Council (FT100203203). Dr. Sands was supported by the American Heart Association (15SDG25890059), National Health and Medical Research Council of Australia (1053201), the Menzies Foundation, American Thoracic Society Foundation, and the National Institute of Health (R01HL128658, 2R01HL102321, P01HL10050580). Dr. Edwards was supported by the National Health and Medical Research Council (NHMRC) of Australia's CJ Martin Overseas Biomedical Fellowship (1035115) and is now supported by a Heart Foundation of Australia Future Leader Fellowship (101167). Dr. Malhotra is PI on NIH R01HL085188, K24HL132105 and coinvestigator on R21HL121794, R01HL119201, R01HL081823. This work was also supported by Harvard Catalyst (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award UL1TR001102).