Journal article

VAGAL AFFERENT INNERVATION OF THE AIRWAYS IN HEALTH AND DISEASE

Stuart B Mazzone, Bradley J Undem

PHYSIOLOGICAL REVIEWS | AMER PHYSIOLOGICAL SOC | Published : 2016

Abstract

Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, functionality, and anatomical organization, and collectively these nerves are essential for the regulation of respiratory physiology and pulmonary defense through local responses and centrally mediated neural pathways. Mechanical and chemical activation of airway afferents depends on a myriad of ionic and receptor-mediated signaling, much of which has yet to be fully explored. Alterations in the sensitivity and neurochemical phenotype of vagal afferent nerves and/or the neural pathways that they innervate occur..

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University of Melbourne Researchers

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by National Heart, Lung, and Blood Institute


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Funding Acknowledgements

S. B. Mazzone holds National Health and Medical Research Council of Australia Grants 1042528, 1025589, and 1078943. B. J. Undem was supported by National Heart, Lung, and Blood Institute Grant HL112919.