Journal article
Absence of toll-IL-1 receptor 8/single immunoglobulin IL-1 receptor-related molecule reduces house dust mite-induced allergic airway inflammation in mice
J Barry, Z Loh, A Collison, S Mazzone, A Lalwani, V Zhang, S Davidson, E Wybacz, C Garlanda, A Mantovani, J Mattes, PS Foster, S Phipps
American Journal of Respiratory Cell and Molecular Biology | AMER THORACIC SOC | Published : 2013
Abstract
Allergic asthma is a chronic inflammatory disease predominately associated with the activation of CD4+ T helper Type 2 (Th2) cells. Innate pattern recognition receptors are widely acknowledged to shape the adaptive immune response. For example, the activation of airway epithelial Toll-like receptor-4 (TLR4) is necessary for the generation of house dust mite(HDM)-specific Th2 responses and the development of asthma in mice. Here we sought to determine whether the absence of Toll-interleukin-1 receptor (TIR)-8, a negative regulator of TLR4 signaling that is highly expressed in airway epithelial cells, would exacerbate HDM-induced asthma in a murine model. We found that Th2 but not Th1 or Th17 ..
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Awarded by National Health and Medical Research Council of Australia Fellowship
Funding Acknowledgements
This work was supported by a National Health and Medical Research Council of Australia Project grant (S. P.), an Australian Lung Foundation/Boehringer Ingelheim Chronic Airflow Limitation Research Fellowship (S. P.), and National Health and Medical Research Council of Australia Fellowship Grant 1025589 (S.M.).