Journal article

Haplotypic variation in the UCP1 gene is associated with milk traits in dairy cows

Huitong Zhou, Long Cheng, Seung Ok Byun, Wumaierjiang Aizimu, Miriam C Hodge, Grant R Edwards, Jon GH Hickford



Uncoupling protein-1 (UCP1) plays a role in the regulation of body temperature, metabolic rate and energy expenditure in animals. While variation in UCP1 and its phenotypic effect has been investigated in humans and sheep, little is known about this gene in cattle. In this study, four regions of bovine UCP1 were investigated in 612 Holstein-Friesian × Jersey (HF × J) dairy cows using polymerase chain reaction-single stranded conformational polymorphism (PCR-SSCP) analyses. In the four regions of the gene analysed, a total of 13 SNPs were detected. Three sequences (a, b and c) were found in Region-2 and three sequences (A, B and C) were found in Region-4, and these were assembled into three (..

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University of Melbourne Researchers


Awarded by Ministry of Science and Innovation

Funding Acknowledgements

Financial support from the Ministry of Science and Innovation (DRCX 0802; Dairy Systems for Environmental Protection; NZ) and Lincoln University Gene-Marker Laboratory are acknowledged. We acknowledge the support of the AGMARDT Postdoctoral Fellowship to Long Cheng. We thank Guo Yang, Innocent Rugoho, Helen Hague, Thomas Vazhathara and Freeman Fang from Lincoln University (NZ) for technical support and useful discussion; and Peter Hancox from Lincoln University Dairy Farm for provision of cows and assistance with sampling.