Journal article
Variation in the bovine FABP4 gene affects milk yield and milk protein content in dairy cows
H Zhou, L Cheng, W Azimu, S Hodge, GR Edwards, JGH Hickford
Scientific Reports | NATURE PORTFOLIO | Published : 2015
DOI: 10.1038/srep10023
Abstract
Fatty acid binding proteins (FABPs) bind long-chain fatty acids and are involved in their intracellular transport. Of the known bovine FABP genes, FABP4 has been mapped to a region on chromosome 14 that contains quantitative trait loci for milk traits. This study investigated the association of FABP4 haplotypes with milk production traits in 719 Holstein-Friesian × Jersey cows. Polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) analysis of a variable region of the gene revealed three haplotypes (A, B and C). Five single nucleotide polymorphisms (SNPs) were identified: two in exon 3 and three in intron 3. A was associated (P = 0.032) with increased milk protein per..
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Awarded by Gene-Marker Laboratory, Lincoln University
Funding Acknowledgements
Financial support from the Ministry of Science and Innovation (DRCX 0802; Dairy Systems for Environmental Protection; NZ) and Lincoln University Gene-Marker Laboratory are acknowledged. Guo Yang, Innocent Rugoho, Helen Hague, Thomas Vazhathara, Seung Byun and Freeman Fang from Lincoln University (NZ) are thanked for technical support and useful discussion. We thank Peter Hancox from Lincoln University Dairy Farm for provision of cows and assistance with sampling. Hinrich Voges from Livestock Improvement Corporation (NZ) is thanked for helping with blood sampling.