Genome-wide estimates of inbreeding in unrelated individuals and their association with cognitive ability.
Robert A Power, Craig Nagoshi, John C DeFries, Robert Plomin, undefined Wellcome Trust Case Control Consortium 2
Eur J Hum Genet | Springer Science and Business Media LLC | Published : 2014
The consequence of reduced cognitive ability from inbreeding has long been investigated, mainly restricted to cousin-cousin marriages. Molecular genetic techniques now allow us to test the relationship between increased ancestral inbreeding and cognitive ability in a population of traditionally unrelated individuals. In a representative UK sample of 2329 individuals, we used genome-wide SNP data to estimate the percentage of the genome covered by runs of homozygous SNPs (ROH). This was tested for association with general cognitive ability, as well as measures of verbal and non-verbal ability. Further, association was tested between these traits and specific ROH. Burden of ROH was not associa..View full abstract
Awarded by Medical Research Council
Awarded by NICHD NIH HHS
Awarded by European Research Council
Awarded by Wellcome Trust