Role of Glomerular Filtration Rate in the Impaired Sodium and Water Excretion of Patients With the Nephrotic Syndrome

Abstract

Hemodynamic and hormonal factors were monitored in nine patients with nephrotic syndrome who were evaluated relative to their capacity to excrete a 20-mL/kg water load (normal > 80%). In five “nonexcretor” patients (37% of water load excreted in five hours), as compared to four normal excretors (105% of water load excreted in five hours; P < .01 v nonexcretors), neither BP (131/88 v 119/79 mm Hg), pulse (74 v 77 beats/min), cardiac index (3.7 v 3.1 L/min/m2), pulmonary wedge pressure (9.3 v 7.3 mm Hg), systemic vascular resistance (1537 v 1254 dynes-sec-cm-5), nor plasma volume (41.3 v 40.1 mL/kg) were different. Similarly, plasma renin activity (2.6 v 3.7 ng/mL/h), plasma aldosterone (12 v ..