Journal article
Defining the relationship between Plasmodium vivax parasite rate and clinical disease
KE Battle, E Cameron, CA Guerra, N Golding, KA Duda, RE Howes, IRF Elyazar, RN Price, JK Baird, RC Reiner, DL Smith, PW Gething, SI Hay
Malaria Journal | BMC | Published : 2015
Open access
Abstract
Background: Though essential to the development and evaluation of national malaria control programmes, precise enumeration of the clinical illness burden of malaria in endemic countries remains challenging where local surveillance systems are incomplete. Strategies to infer annual incidence rates from parasite prevalence survey compilations have proven effective in the specific case of Plasmodium falciparum, but have yet to be developed for Plasmodium vivax. Moreover, defining the relationship between P. vivax prevalence and clinical incidence may also allow levels of endemicity to be inferred for areas where the information balance is reversed, that is, incident case numbers are more widely..
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Awarded by Medical Research Council
Funding Acknowledgements
SIH is funded by a Senior Research Fellowship from the Wellcome Trust (095066), which also supports KEB, KAD and REH. NG is funded by a grant from the Bill & Melinda Gates Foundation (OPP1053338). IRFE is funded by a Public Health and Tropical Medicine Fellowship of the Wellcome Trust (B9RZGS0). RNP is a Wellcome Trust Senior Fellow in Clinical Science (091625). JKB is supported by Wellcome Trust grant (B9RJIXO). PWG is a Career Development Fellow (#K00669X) jointly funded by the UK Medical Research Council (MRC) and the UK Department for International Development (DFID) under the MRC/DFID Concordat agreement and receives support from the Bill & Melinda Gates Foundation (#OPP1068048, #OPP1106023), which also supports EC. DLS is funded by a grant from the Bill & Melinda Gates Foundation (OPP1110495), which also supports RCR. RCR, DLS and SIH also acknowledge funding support from the RAPIDD program of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health.