Journal article
Global temperature constraints on Aedes aegypti and Ae. albopictus persistence and competence for dengue virus transmission
OJ Brady, N Golding, DM Pigott, MUG Kraemer, JP Messina, RC Reiner, TW Scott, DL Smith, PW Gething, SI Hay
Parasites and Vectors | BMC | Published : 2014
Abstract
Background: Dengue is a disease that has undergone significant expansion over the past hundred years. Understanding what factors limit the distribution of transmission can be used to predict current and future limits to further dengue expansion. While not the only factor, temperature plays an important role in defining these limits. Previous attempts to analyse the effect of temperature on the geographic distribution of dengue have not considered its dynamic intra-annual and diurnal change and its cumulative effects on mosquito and virus populations. Methods. Here we expand an existing modelling framework with new temperature-based relationships to model an index proportional to the basic re..
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Funding Acknowledgements
OJB is funded by a BBSRC studentship. PWG is a Medical Research Council (UK) Career Development Fellow (#K00669X) and receives support from the Bill and Melinda Gates Foundation (#OPP1068048). NG is funded by a grant from the Bill & Melinda Gates Foundation (#OPP1053338). SIH is funded by a Senior Research Fellowship from the Wellcome Trust (095066). MUGK is funded by the German Academic Exchange Service (DAAD) through a graduate scholarship. This study was partially funded by EU grant 21803 IDAMS (http://www.idams.eu) and is designated with IDAMS publication reference number IDAMS22. The contents of this publication are the sole responsibility of the authors and don't necessarily reflect the views of the European Commission. T.W.S. acknowledges funding from the Bill & Melinda Gates Foundation (OPP52250), the Innovative Vector Control Consortium, and the NIH (R01-AI069341, R01-AI091980, and R01-GM08322). RCR, TWS, DLS and SIH also acknowledges funding support from the Research and Policy in Infectious Disease Dynamics (RAPIDD) program of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health.