Journal article
Geographical variation in Plasmodium vivax relapse
KE Battle, MS Karhunen, S Bhatt, PW Gething, RE Howes, N Golding, TP Van Boeckel, JP Messina, GD Shanks, DL Smith, JK Baird, SI Hay
Malaria Journal | BMC | Published : 2014
Abstract
Background: Plasmodium vivax has the widest geographic distribution of the human malaria parasites and nearly 2.5 billion people live at risk of infection. The control of P. vivax in individuals and populations is complicated by its ability to relapse weeks to months after initial infection. Strains of P. vivax from different geographical areas are thought to exhibit varied relapse timings. In tropical regions strains relapse quickly (three to six weeks), whereas those in temperate regions do so more slowly (six to twelve months), but no comprehensive assessment of evidence has been conducted. Here observed patterns of relapse periodicity are used to generate predictions of relapse incidence..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by a Wellcome Trust Senior Research Fellowship (#095066) held by SIH, which also supports KEB, MSK and REH. PWG is a Medical Research Council Career Development Fellow (#K00669X) and receives support from the Bill and Melinda Gates Foundation (#OPP1068048) that also supports SB. NG is funded by a grant from the Bill & Melinda Gates Foundation (#OPP1053338). JPM is funded by the International Research Consortium on Dengue Risk Assessment Management and Surveillance (IDAMS, European Commission 7th Framework Programme (#21803)). TPVB was funded by a grant from the Belgian Fond National pour la Recherche Scientifique and the Fondation Wiener-Anspach. DLS and SIH acknowledge funding support from the RAPIDD program of the Science & Technology Directorate, Department of Homeland Security, and the Fogarty International Center, National Institutes of Health. JKB is supported by Wellcome Trust grant #B9RJIXO.