Environmental enrichment enhances cognitive flexibility in C57BL/6 mice on a touchscreen reversal learning task
Ariel Zeleznikow-Johnston, Emma L Burrows, Thibault Renoir, Anthony J Hannan
NEUROPHARMACOLOGY | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2017
Environmental enrichment (EE) is any positive modification of the 'standard housing' (SH) conditions in which laboratory animals are typically held, usually involving increased opportunity for cognitive stimulation and physical activity. EE has been reported to enhance baseline performance of wild-type animals on traditional cognitive behavioural tasks. Recently, touchscreen operant testing chambers have emerged as a way of performing rodent cognitive assays, providing greater reproducibility, translatability and automatability. Cognitive tests in touchscreen chambers are performed over numerous trials and thus experimenters have the power to detect subtle enhancements in performance. We use..View full abstract
Awarded by ARC FT3 Future Fellowship
Awarded by NHMRC
ELB is supported by a National Health and Medical Research Council (NHMRC) Australian Research Council (ARC) Dementia Research Development Fellowship. AJH is an NHMRC Principal Research Fellow (GNT1117148) and has been supported by an ARC FT3 Future Fellowship (FT100100835). TR is an ARC DECRA Fellow. AZJ is supported by the Australian Government Research Training Program Scholarship. This work was supported by an NHMRC Project Grant (GNT1126885). We would also like to acknowledge the operational infrastructure support from the State Government of Victoria. The authors declare no conflict of interest.