Journal article

The Basal Radial Glia Occurs in Marsupials and Underlies the Evolution of an Expanded Neocortex in Therian Mammals

Christine Sauerland, Brandon R Menzies, Megan Glatzle, Johannes Seeger, Marilyn B Renfree, Simone A Fietz

Cerebral Cortex | Oxford University Press (OUP) | Published : 2018

Abstract

A hallmark of mammalian brain evolution is the emergence of the neocortex, which has expanded in all mammalian infraclasses (Eutheria, Marsupialia, Monotremata). In eutherians, neocortical neurons derive from distinct neural stem and progenitor cells (NPCs). However, precise data on the presence and abundance of the NPCs, especially of basal radial glia (bRG), in the neocortex of marsupials are lacking. This study characterized and quantified the NPCs in the developing neocortex of a marsupial, the tammar wallaby (Macropus eugenii). Our data demonstrate that its neocortex is characterized by high NPC diversity. Importantly, we show that bRG exist at high relative abundance in the tammar indi..

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Grants

Awarded by Deutscher Akademischer Austauschdienst/German Academic Exchange Service (DAAD)


Awarded by Deutsche Forschungsgemeinschaft/German Research Foundation (DFG)


Funding Acknowledgements

Deutscher Akademischer Austauschdienst/German Academic Exchange Service (DAAD, Project 57141544 to S.A.F) and the Deutsche Forschungsgemeinschaft/German Research Foundation (DFG, FI 1565/3-1 to S.A.F.); Australian GO8 (travel grant to M.B.R. and B.R.M.).