Journal article
Characterizing cognitive heterogeneity on the schizophrenia-bipolar disorder spectrum
TE Van Rheenen, KE Lewandowski, EJ Tan, LH Ospina, D Ongur, E Neill, C Gurvich, C Pantelis, AK Malhotra, SL Rossell, KE Burdick
Psychological Medicine | CAMBRIDGE UNIV PRESS | Published : 2017
Abstract
Background Current group-average analysis suggests quantitative but not qualitative cognitive differences between schizophrenia (SZ) and bipolar disorder (BD). There is increasing recognition that cognitive within-group heterogeneity exists in both disorders, but it remains unclear as to whether between-group comparisons of performance in cognitive subgroups emerging from within each of these nosological categories uphold group-average findings. We addressed this by identifying cognitive subgroups in large samples of SZ and BD patients independently, and comparing their cognitive profiles. The utility of a cross-diagnostic clustering approach to understanding cognitive heterogeneity in these..
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Awarded by National Institute of Mental Health
Funding Acknowledgements
This research was supported by the Australian National Health and Medical Research Council [fellowships to T.E.V.R. (APP1088785) and C.G. (APP546262) and project grant to S.L.R. (APP1060664)], the Helen McPherson Smith Trust (to T.E.V.R., S.L.R.), the Australian Rotary Health/Bipolar Expedition (to T.E.V.R., S.L.R.), the National Institute of Mental Health (MH101267; R01 MH102257, R03MH079995; K23MH077807; R01MH100125 to K.E.B.; K23MH091210 to K.E.L.; K24MH104449 to D.O.) and the Veterans Health Administration (I01CX000995 to K.E.B.).