Journal article
Catheter-Based Renal Denervation Exacerbates Blood Pressure Fall During Hemorrhage
RR Singh, V Sajeesh, LC Booth, Z McArdle, CN May, GA Head, KM Moritz, MP Schlaich, KM Denton
Journal of the American College of Cardiology | ELSEVIER SCIENCE INC | Published : 2017
Abstract
Background Clinical trials applying catheter-based radiofrequency renal denervation (RDN) demonstrated a favorable safety profile with minimal acute or procedural adverse events. Whether ablation of renal nerves adversely affects compensatory responses to hemodynamic challenge has not been extensively investigated. Objectives The aim of this study was to examine the effect of RDN on mean arterial pressure, renal function, and the reflex response to hemorrhage in sheep with normotension (control) or with hypertensive chronic kidney disease (CKD). Methods Sheep underwent RDN (control-RDN, n = 8; CKD-RDN, n = 7) or sham procedures (control-intact, n = 6; CKD-intact, n = 7). Response to hemorrha..
View full abstractGrants
Awarded by National Health Research Council of Australia
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
This research was supported by a project grant (#1046594) and fellowships to Prof. Denton (#1041844), Prof. Moritz (#1078164), Prof. Schlaich (#1080404), and Dr. Booth (#1054619) from the National Health Research Council of Australia. Prof. Schlaich is an investigator in studies sponsored by Medtronic, and his laboratories have received research funding from Medtronic. Prof. Schlaich serves on scientific advisory boards for Abbott (formerly Solvay) Pharmaceuticals, Boehringer Ingelheim, Novartis Pharmaceuticals, and Medtronic; and has received honoraria and travel support from Abbott, Boehringer Ingelheim, Servier, Novartis, and Medtronic. Prof. May has received honoraria and travel support for presentations from Medtronic. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.