Journal article
APOEɛ4 Genotype, Amyloid, and Clinical Disease Progression in Cognitively Normal Older Adults
S Hollands, YY Lim, SM Laws, VL Villemagne, RH Pietrzak, K Harrington, T Porter, P Snyder, D Ames, C Fowler, SR Rainey-Smith, RN Martins, O Salvado, J Robertson, CC Rowe, CL Masters, P Maruff
Journal of Alzheimer S Disease JAD | IOS PRESS | Published : 2017
DOI: 10.3233/JAD-161019
Abstract
BACKGROUND: In cognitively normal (CN) older adults, carriage of the apolipoprotein E (APOE) ɛ4 allele is associated with increased risk for dementia of the Alzheimer type (AD-dementia). It is unclear whether this occurs solely through APOEɛ4 increasing amyloid-β (Aβ) accumulation or through processes independent of Aβ.OBJECTIVE: To determine the extent and nature to which APOEɛ4 increases risk for clinical disease progression in CN older adults.METHODS: Data from the total (n = 765) and Aβ-imaged (n = 423) CN cohort in the Australian Imaging, Biomarker and Lifestyle (AIBL) Study of Ageing was analyzed using Cox proportional hazard models to estimate ɛ4 risk for clinical disease progression ..
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Funding Acknowledgements
Funding for the study was provided in part by the study partners (Common wealth Scientific Industrialand research Organization [CSIRO], Edith Cowan University [ECU], Mental Health Research institute [MHRI], National Ageing Research Institute[NARI], Austin Health, CogState Ltd). The study also received support from the National Health and Medical Research Council (NHMRC) and the Dementia Collaborative Research Centres program (DCRC2), as well as funding from the Science and Industry Endowment Fund (SIEF) and the Cooperative Research Centre (CRC) for Mental Health, an Australian Government Initiative.