Journal article
Prediction of acute coronary syndromes by urinary proteome analysis
NM Htun, DJ Magliano, ZY Zhang, J Lyons, T Petit, E Nkuipou-Kenfack, A Ramirez-Torres, C Von Zur Muhlen, D Maahs, JP Schanstra, C Pontillo, M Pejchinovski, JK Snell-Bergeon, C Delles, H Mischak, JA Staessen, JE Shaw, T Koeck, K Peter
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2017
Abstract
Identification of individuals who are at risk of suffering from acute coronary syndromes (ACS) may allow to introduce preventative measures. We aimed to identify ACS-related urinary peptides, that combined as a pattern can be used as prognostic biomarker. Proteomic data of 252 individuals enrolled in four prospective studies from Australia, Europe and North America were analyzed. 126 of these had suffered from ACS within a period of up to 5 years post urine sampling (cases). Proteomic analysis of 84 cases and 84 matched controls resulted in the discovery of 75 ACS-related urinary peptides. Combining these to a peptide pattern, we established a prognostic biomarker named Acute Coronary Syndro..
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Awarded by European Commission
Funding Acknowledgements
The project was partly supported by the European Union grants EU-MASCARA (HEALTH-FP7-278249), HOMAGE (HEALTH-FP7-305507), SYSVASC (HEALTH-FP7-603288), the European Research Council Advanced Researcher Grant EXPLORE (2011-294713) and the National Health and Medical Research Council of Australia (NHMRC) - European Union Collaborative Research Grant GNT1102158. The Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13 and G.0880.13) supported the FLEMENGHO study. N. M. Htun was supported by scholarships from the Cardiac Society of Australia and New Zealand (CSANZ) and NHMRC, Australia. D. J. Magliano, J. E. Shaw and K. Peter are supported by research fellowships from the NHMRC. The funders provided support in the form of salaries for authors [NMH, DJM, ENK, JPS, CD, HM, JAS, JES, TK, KP], but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the author contributions section.