Journal article

A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study

Rebecca K Simmons, Knut Borch-Johnsen, Torsten Lauritzen, Guy EHM Rutten, Annelli Sandaek, Maureen van den Donk, James A Black, Libo Tao, Edward CF Wilson, Melanie J Davies, Kamlesh Khunti, Stephen J Sharp, Nicholas J Wareham, Simon J Griffin



BACKGROUND: Intensive treatment (IT) of cardiovascular risk factors can halve mortality among people with established type 2 diabetes but the effects of treatment earlier in the disease trajectory are uncertain. OBJECTIVE: To quantify the cost-effectiveness of intensive multifactorial treatment of screen-detected diabetes. DESIGN: Pragmatic, multicentre, cluster-randomised, parallel-group trial. SETTING: Three hundred and forty-three general practices in Denmark, the Netherlands, and Cambridge and Leicester, UK. PARTICIPANTS: Individuals aged 40-69 years with screen-detected diabetes. INTERVENTIONS: Screening plus routine care (RC) according to national guidelines or IT comprising screening ..

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University of Melbourne Researchers


Awarded by NIHR Health Technology Assessment programme

Awarded by Department of Health NIHR Programme Grants

Awarded by MRC

Awarded by Medical Research Council

Awarded by National Institute for Health Research

Funding Acknowledgements

[ "The ADDITION-Netherlands study was supported by unrestricted grants from Novo Nordisk, GlaxoSmithKline and Merck and by the Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht.", "The ADDITION-Leicester was supported by the Department of Health and ad hoc Support Sciences, the NIHR Health Technology Assessment programme (grant reference number 08/116/300), NHS R&D support funding [including the Primary Care Research and Diabetes Research Networks and the Leicestershire, Northampton and Rutland (LNR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC)] and the NIHR. MJD and KK receive support from the Department of Health NIHR Programme Grants for Applied Research funding scheme (grant reference number RP-PG-0606-1272)." ]