Journal article
A randomised trial of the effect and cost-effectiveness of early intensive multifactorial therapy on 5-year cardiovascular outcomes in individuals with screen-detected type 2 diabetes: the Anglo-Danish-Dutch Study of Intensive Treatment in People with Screen-Detected Diabetes in Primary Care (ADDITION-Europe) study
Rebecca K Simmons, Knut Borch-Johnsen, Torsten Lauritzen, Guy EHM Rutten, Annelli Sandaek, Maureen van den Donk, James A Black, Libo Tao, Edward CF Wilson, Melanie J Davies, Kamlesh Khunti, Stephen J Sharp, Nicholas J Wareham, Simon J Griffin
Health Technology Assessment | NIHR JOURNALS LIBRARY | Published : 2016
DOI: 10.3310/hta20640
Abstract
BACKGROUND: Intensive treatment (IT) of cardiovascular risk factors can halve mortality among people with established type 2 diabetes but the effects of treatment earlier in the disease trajectory are uncertain. OBJECTIVE: To quantify the cost-effectiveness of intensive multifactorial treatment of screen-detected diabetes. DESIGN: Pragmatic, multicentre, cluster-randomised, parallel-group trial. SETTING: Three hundred and forty-three general practices in Denmark, the Netherlands, and Cambridge and Leicester, UK. PARTICIPANTS: Individuals aged 40-69 years with screen-detected diabetes. INTERVENTIONS: Screening plus routine care (RC) according to national guidelines or IT comprising screening ..
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Awarded by NIHR Health Technology Assessment programme
Awarded by Department of Health NIHR Programme Grants
Awarded by Medical Research Council
Awarded by National Institute for Health Research
Funding Acknowledgements
The ADDITION-Netherlands study was supported by unrestricted grants from Novo Nordisk, GlaxoSmithKline and Merck and by the Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht.The ADDITION-Leicester was supported by the Department of Health and ad hoc Support Sciences, the NIHR Health Technology Assessment programme (grant reference number 08/116/300), NHS R&D support funding [including the Primary Care Research and Diabetes Research Networks and the Leicestershire, Northampton and Rutland (LNR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC)] and the NIHR. MJD and KK receive support from the Department of Health NIHR Programme Grants for Applied Research funding scheme (grant reference number RP-PG-0606-1272).