Journal article
Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation
CP Molloy, Y Yao, H Kammoun, T Bonnard, T Hoefer, K Alt, F Tovar-Lopez, G Rosengarten, PA Ramsland, AD van der Meer, A van den Berg, AJ Murphy, CE Hagemeyer, K Peter, E Westein
Journal of Thrombosis and Haemostasis | WILEY | Published : 2017
DOI: 10.1111/jth.13666
Abstract
Essentials Vessel stenosis due to large thrombus formation increases local shear 1-2 orders of magnitude. High shear at stenotic sites was exploited to trigger eptifibatide release from nanocapsules. Local delivery of eptifibatide prevented vessel occlusion without increased tail bleeding times. Local nanocapsule delivery of eptifibatide may be safer than systemic antiplatelet therapies. Summary: Background Myocardial infarction and stroke remain the leading causes of mortality and morbidity. The major limitation of current antiplatelet therapy is that the effective concentrations are limited because of bleeding complications. Targeted delivery of antiplatelet drug to sites of thrombosis wou..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by grants from the National Health and Medical Research Council Australia (NHMRC; 1083138 and 1050018) and Perpetual grants Australia (FR2014/0941). C. E. Hagemeyer and E. Westein were supported by the National Heart Foundation (CR 11M 6066, 100123). A. J. Murphy is supported by a career development fellowship from the NHMRC (APP1085752) and a future leader fellowship from the National Heart Foundation (100440). K. Peter is supported by an NHMRC fellowship (1079492). We thank I. Ung for technical assistance with the in vitro blood perfusion experiments. The authors gratefully acknowledge the contribution to this study from the Victorian Operational Infrastructure Support Program.