Journal article
Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia
LM Dowman, CF McDonald, S Bozinovski, R Vlahos, R Gillies, D Pouniotis, CJ Hill, NSL Goh, AE Holland
Respirology | WILEY | Published : 2017
DOI: 10.1111/resp.13002
Abstract
Background and objective: Supplemental oxygen is commonly prescribed in patients with idiopathic pulmonary fibrosis (IPF), although its benefits have not been proven. The aims of this study were to investigate the effect of oxygen on oxidative stress, cytokine production, skeletal muscle metabolism and physiological response to exercise in IPF. Methods: Eleven participants with IPF received either oxygen, at an FiO2 of 0.50, or compressed air for 1 h at rest and during a cycle endurance test at 85% of peak work rate. Blood samples collected at rest and during exercise were analysed for markers of oxidative stress, skeletal muscle metabolism and cytokines. The protocol was repeated a week lat..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors would like to acknowledge the contributions of the members of the Respiratory and Sleep Medicine Department for their assistance with the cardiopulmonary exercise testing and the members of the Pathology Department for collection of the final blood sample. We would also like to thank the participants of this study for their time and cooperation. Sources of support include: the Pulmonary Fibrosis Foundation/American Thoracic Society Foundation, the Institute for Breathing and Sleep, the Eirene Lucas Foundation and the National Health and Medical Research Council (Grant ID: GNT1017802).