Journal article

Novel technique to determine the pK(A) of clonidine at prejunctional alpha(2)-adrenoceptors in cardiac and vascular sympathetic transmission

James A Angus, Pravin Rajasekaran, Christine E Wright

European Journal of Pharmacology | ELSEVIER SCIENCE BV | Published : 2017

DOI: 10.1016/j.ejphar.2017.02.030

Keywords

Pharmacology & Pharmacy
Hypertension
Norepinephrine
Prazosin
Science & Technology
Synaptic Transmission
Antagonism
Alpha(2)-Adrenoceptors
Presynaptic Receptors
Clonidine
Rat
Mesenteric Artery
Prazosin Hydrochloride (pubchem Cid: 68546)
Yohimbine
Neuronal Uptake
Regulating Noradrenaline Overflow
Atria
Dose-Response Relationship, Drug
Heart Atria
Mesenteric Arteries
Male
Rats
(-)-Noradrenaline Bitartrate (pubchem Cid: 18530234)
(±)-Propranolol Hydrochloride (pubchem Cid: 62882)
Alpha-Adrenoceptor
Mice
Receptors, Adrenergic, Alpha-2
Guinea-Pig
Desipramine
Life Sciences & Biomedicine
Clonidine Hydrochloride (pubchem Cid: 20179)
Guinea Pigs
Benextramine Tetrahydrochloride (pubchem Cid: 2317)
Cystamine
Animals
Desipramine Hydrochloride (pubchem Cid: 65327)
Benextramine
Right Atria
and Yohimbine Hydrochloride (pubchem Cid: 6169)
Sympathetic Nervous System
Α(2)-Adrenoceptors
Nerve-Stimulation