Journal article
The cardiovascular and neurotoxic effects of the venoms of six bony and cartilaginous fish species
H Han, K Baumann, NR Casewell, SA Ali, J Dobson, I Koludarov, J Debono, SC Cutmore, NW Rajapakse, TNW Jackson, R Jones, WC Hodgson, BG Fry, S Kuruppu
Toxins | MDPI | Published : 2017
Abstract
Fish venoms are often poorly studied, in part due to the difficulty in obtaining, extracting, and storing them. In this study, we characterize the cardiovascular and neurotoxic effects of the venoms from the following six species of fish: the cartilaginous stingrays Neotrygon kuhlii and Himantura toshi, and the bony fish Platycephalus fucus, Girella tricuspidata, Mugil cephalus, and Dentex tumifrons. All venoms (10–100 μg/kg, i.v.), except G. tricuspidata and P. fuscus, induced a biphasic response on mean arterial pressure (MAP) in the anesthetised rat. P. fucus venom exhibited a hypotensive response, while venom from G. tricuspidata displayed a single depressor response. All venoms induced ..
View full abstractGrants
Awarded by Natural Environment Research Council
Funding Acknowledgements
This research was funded by the Australian Research Council and the Herman Slade Foundation. Kate Baumann, Jordan Debono, and Ivan Koludarov were the recipients of post-graduate scholarships from the University of Queensland. Nicholas R. Casewell was funded by a UK Natural Environment Research Council Postdoctoral Research Fellowship. Scott C Cutmore was funded by an ABRS National Taxonomy Research Grant.