Visceral adiposity predicts post-operative Crohn's disease recurrence

Abstract

Background: Excessive visceral adipose tissue has been associated with poorer outcomes in patients with inflammatory bowel disease. Aim: To determine whether body composition is associated with outcome in a prospective study of post-operative Crohn's disease patients. Methods: The POCER study evaluated management strategies for prevention of post-operative Crohn's disease recurrence; subjects were enrolled after resection of all macroscopic Crohn's disease and were randomised to early endoscopy and possible treatment escalation, or standard care. The primary endpoint was endoscopic recurrence at 18 months. 44 subjects with cross-sectional abdominal imaging were studied, and body composition ..