Journal article
Sex differences in long-term mortality after stroke in INSTRUCT (INternational STRoke oUtComes sTudy)
HT Phan, CL Blizzard, MJ Reeves, AG Thrift, D Cadilhac, J Sturm, E Heeley, P Otahal, V Konstantinos, C Anderson, P Parmar, R Krishnamurthi, S Barker-Collo, V Feigin, Y Bejot, NL Cabral, A Carolei, S Sacco, N Chausson, S Olindo Show all
Circulation Cardiovascular Quality and Outcomes | Published : 2017
Abstract
Background - Women are reported to have greater mortality after stroke than men, but the reasons are uncertain. We examined sex differences in mortality at 1 and 5 years after stroke and identified factors contributing to these differences. Methods and Results - Individual participant data for incident strokes were obtained from 13 population-based incidence studies conducted in Europe, Australasia, South America, and the Caribbean between 1987 and 2013. Data on sociodemographics, stroke-related factors, prestroke health, and 1- and 5-year survival were obtained. Poisson modeling was used to estimate the mortality rate ratio (MRR) for women compared with men at 1 year (13 studies) and 5 year..
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Awarded by Wellcome Trust
Funding Acknowledgements
Chief investigators for each of the studies provided their data at no cost. Dr Phan is supported by a Merle Weaver Postgraduate Scholarship (University of Tasmania). Dr Gall is supported by a National Heart Foundation of Australia Future Leader Fellowship (FLF 100446). Dr Reeves was supported by a Menzies Institute Visiting scholars program (Tasmania, Australia). The following authors received research fellowship funding from the National Health and Medical Research Council: Dr Thrift (1042600), Dr Cadilhac (cofunded Heart Foundation: 1063761), and Dr Anderson (1081356). The Health Research Council of New Zealand funded the research conducted in Auckland. The Brazilian National Council for Scientific and Technological Development (CNPq) funded the research conducted in Joinville (402396/2013-8). The Dijon Stroke Registry is supported by InVS and INSERM. The Oxford Vascular Study is funded by the Wellcome Trust, Stroke Association, and the National Institute of Health Research Biomedical Research Centre, Oxford.