Journal article

Macrophage physiology in the eye

Holly R Chinnery, Paul G McMenamin, Samantha J Dando



The eye is a complex sensory organ composed of a range of tissue types including epithelia, connective tissue, smooth muscle, vascular and neural tissue. While some components of the eye require a high level of transparency to allow light to pass through unobstructed, other tissues are characterized by their dense pigmentation, which functions to absorb light and thus control its passage through the ocular structures. Macrophages are present in all ocular tissues, from the cornea at the anterior surface through to the choroid/sclera at the posterior pole. This review will describe the current understanding of the distribution, phenotype, and physiological role of ocular macrophages, and prov..

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Awarded by National Health and Medical Research Council

Awarded by Medical Research Foundation

Funding Acknowledgements

Funding for HRC: National Health and Medical Research Council APP 1042612, PGM: National Health and Medical Research Council APP 1069979, and SD: Rebecca L. Cooper Medical Research Foundation APP 10470. The authors acknowledge Dr. Cecilia Naranjo Golborne for her excellent confocalmicroscopy skills; the Florey Advanced Microscopy Facility at The Florey Institute of Neuroscience & Mental Health Facility for provision of instrumentation, training, and general support and the facilities, scientific, and technical assistance of Monash Micro Imaging, Monash Histology Platform, and Monash Flow Core, Monash University, Victoria, Australia.