Journal article
The interaction between farming/rural environment and TLR2, TLR4, TLR6 and CD14 genetic polymorphisms in relation to early-and late-onset asthma
MYZ Lau, SC Dharmage, JA Burgess, AK Win, AJ Lowe, C Lodge, J Perret, J Hui, PS Thomas, S Morrison, GG Giles, J Hopper, MJ Abramson, EH Walters, MC Matheson
Scientific Reports | NATURE PORTFOLIO | Published : 2017
DOI: 10.1038/srep43681
Abstract
Asthma phenotypes based on age-of-onset may be differently influenced by the interaction between variation in toll-like receptor (TLR)/CD14 genes and environmental microbes. We examined the associations between single-nucleotide polymorphisms (SNP) in the TLR/CD14 genes and asthma, and their interaction with proxies of microbial exposure (childhood farm exposure and childhood rural environment). Ten SNPs in four genes (TLR2, TLR4, TLR6, CD14) were genotyped for 1,116 participants from the Tasmanian Longitudinal Health Study (TAHS). Using prospectively collected information, asthma was classified as never, early-(before 13 years) or late-onset (after 13 years). Information on childhood farm e..
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Funding Acknowledgements
We thank the TAHS participants and all previous investigators of the TAHS. We acknowledge the Tasmanian State Achives for providing access to the school medical records and all the respiratory scientists who collected laboratory data in Tasmania, Victoria, Queensland and New South Wales. All participant blood samples were processed and DNA was extracted in the Genetic Epidemiology Laboratory (southeylab.org), The University of Melbourne. This study was funded by the National Health and Medical Research Council of Australia (NHMRC). M.Y.Z. Lau is supported by Marjory Edwards OAM PhD Scholarship from the Asthma Australia. M.C. Matheson, S.C. Dharmage, A.J. Lowe, J.A. Burgess, and A.K. Win are supported by the NHMRC.